Answer: B. In hypoxic tissues, in contrast to normoxic tissues, ATP is additionally consumed to transform lactate to pyruvate
Explanation:
In hypoxic tissues such as new cancerous cells, the vascular system is still underdeveloped, thus oxygen supply is reduced. To meet energy need, additional glucose is needed to convert lactate (result of anaerobic glycolysis) to pyruvate which can then go into the TCA cycle to yield energy. This phenomenon is very common in muscle tissues during exercise.
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