<h2>Scurvy </h2>
Explanation:
(a) Collagen is the major structural component of cartilage,bones and tendons
- The basic unit of collagen is tropocollagen and each tropocollagen consists of three coiled left handed polypeptide chains called α chains
- Generally each α chain consists of a repeating tripeptide sequence called: G-X-Y
- Here G represents glycine; X represents proline and Y represents hydroxyproline
- Rigidity of collagen molecule is due to presence of proline and hydroxyproline
- Hydroxylation of proline is catalysed by prolyl hydroxylase enzyme which use ascorbate,α ketoglutarate and oxygen
- α ketoglutarate is oxidatively decarboxylated to form carbon dioxide and succinate
- Sequence of events leading from a dietary vitamin C deficiency to symptoms such as bruising and breakdown of supporting tissues includes: tissue levels of ascorbic acid is low; enzyme prolyl hydroxylase is inactive; proline is not hydroxylated; the triple helix is inadequately stabilized; collagen breaks down; defects in tissues that depend on collagen
; tissues that depend on collagen are subject to breakdown and bruising
(b) Sailors are no longer susceptible to scurvy because fresh fruits which are the source of vitamin C source are available now
British sailors called "limeys" to this day,this term reflects the British navy's use of limes
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Answer:
Development is largely under the control of genes. Mature cell types of the body, like neurons and liver cells, express different sets of genes, which give them their unique properties and functions.
Explanation:
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Answer:
a. The operon is under positive control
a.) Loss of enzyme synthesis results from loss of regulatory R gene product which is regulated in the presence of Tis ophane for transcription. Absence of (Tis), transcription is positively controlled by regulatory Rprotein
b.) The proposed model reveals Tis / B complex prevents Tis enzymes from undergoing transcription through the RB operator by binding to the B region
the role of the R protein is
-decrease affinity of Tis / B complex to B region of RB
-bind to the R region on RB
- change the conformation of B region
- yield decreased affinity of Tis / B complex when R gene is lacking preventing transcription in the process
Effects of the RB mutations is that R protein will not bind to Tis / B complex to reduce transcription