Carbohydrates, lipids, nucleic acids, and proteins
Mutations result either from errors in DNA replication or from the damaging effects of mutagens, such as chemicals and radiation, which react with DNA and change the structures of individual nucleotides. All cells possess DNA-repair enzymes that attempt to minimize the number of mutations that occur
Vitamins. A lot of coenzymes are derivatives os vitamins especially B vitamins.
Hope this helps:)
It was used till the 1960s. Hope i helped.