The sequence of amino acid in polypeptide is dictated by the codons in the messenger RNA molecules from which polypeptide was translated. The sequence of codons in the mRNA was in turn dictated by the sequence of codons in the DNA from which the mRNA was transcribed. The amino acids are linked covalently by peptide bonds.
Proteins are made inside cells. When a cell makes a protein it is called protein synthesis.
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As both fill with liquid they expand. They are also both rounded shapes