Answer:
<u>Polygenic therapies are more likely to show </u><u>unintended effects</u><u> in other regions of the genome likely resulting in harmful diseases.</u>
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Explanation:
Gene therapy involves biotechnological techniques that add or remove gene sequences in the genome. These are typically used in eliminating harmful genes that cause genetic diseases or disorders and are generally thought to improve an individual's quality of life.
Polygenic traits are controlled by several genes. Similarly, polygenic diseases may be caused by variations in several gene sequences. These include hypertension, heart disease, and diabetes. Polygenic therapies are more likely to show unintended effects in other regions of the genome, leading to other deleterious disease-causing effects.
Answer:
Optimum pH= 6
Optimum pH for the given enzyme would be the average of pKa values of two amino acids (2.9 + 9.1 /2= 6)
Explanation:
The pKa represents the association constant of amino acids. It is calculated by taking the negative log value of the ratio of a dissociated acid and the conjugated base which in turn regulates the isoelectric point (pI) of the protein.
The amino acids present in the active site of the enzyme regulate the interaction of enzyme and substrate. The given enzyme contains two ionizable amino acids with pKa values of 2.9 and 9.1 respectively. Therefore, the optimum pH of the given enzyme would be 2.9 + 9.1 / 2 = 12/2 = 6.
At pH 6, both the ionizable amino acids would serve as a good buffer with their active proton donor and proton acceptor species.
<span>The main reason that the spores of disease-causing bacteria are dangerous is that they are very difficult to destroy. If the bacteria is not suited in the condition state of the environmental, other kinds transform to an inactive state. They advance with a hard outer covering and look out for the suitable environmental conditions. This lie dormant bacterium is known as spores. Spores are more difficult to destroy than those bacteria that are active for they have a harder outer covering.</span>
