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Cells that support viral replication are called permissive. Infections of permissive cells are usually productive because infectious progeny virus is produced. Most productive infections are called cytocidal (cytolytic) because they kill the host cell. Infections of nonpermissive cells yield no infectious progeny virus and are called abortive. When the complete repertoire of virus genes necessary for virus replication is not transcribed and translated into functional products the infection is referred to as restrictive. In persistent and in some transforming infections, viral nucleic acid may remain in specific host cells indefinitely; progeny virus may or may not be produced.
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Affected infants uniformly have significant hypotonia, feeding difficulties, and failure to thrive (FTT), followed in later infancy or early childhood by excessive appetite with gradual development of obesity, short stature and/or decreased growth velocity, intellectual disabilities (average IQ of 65), and behavioral problems (e.g., temper tantrums, outburst, and skin picking
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The correct answer is - A. Report this as a serious adverse event (SAE).
Explanation:
A serious adverse effect (SAE) is a condition that can cause a threat to the patient's life or functioning. As here the research site staff becomes aware and knows of a participant's death searching through public records it is called a serious adverse effect (SAE).
Thus, the correct answer is - A. Report this as a serious adverse event (SAE).