The sequence of nucleotides, coded in triplets (codons) along the mRNA, that determines the sequence of amino acids in protein synthesis. The DNA sequence of a gene can be used to predict the mRNA sequence, and the genetic code can in turn be used to predict the amino acid sequence.
sickle cell anemia is caused by a mutation in the hemoglobin beta (or HBB) gene and it leads to a single change in amino acid sequence. this gene is located on chromosome 19
