blockade of the human ether-a-go-go-related gene (hERG) encoded rapidly activating delayed rectifier potassium (IKr) of cardiac cells
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What are human ether-a-go-go-related gene (hERG)
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- The rapidly activating delayed rectifier potassium channel's pore-forming component is encoded by the human ether-a-go-go-related gene (hERG) (IKr).
- Acquired long-QT syndrome, which puts people at risk for ventricular arrhythmias and sudden death, is mostly caused by drug- or illness-mediated alteration of hERG activity.
- Abuse and fatality rates related to fentanyl have been on the rise recently, raising severe health concerns.
- We looked into how fentanyl affects the hERG channel because it frequently results in abrupt death.
- We also looked at the effects of norfentanyl, the primary metabolite, and naloxone, an antidote for fentanyl overdose. HEK293 cell currents of hERG channels that were persistently expressed were captured using the whole-cell voltage-clamp technique.
To learn more about cardiac cells with the given link
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I believe it is water, I may be wrong though. It's been a while since I studied that stuff.
Most of the terrestrial diversity is found in tropical forests and in general, land has more species than the ocean; some 8.7 million species may exists on Earth, of which some 2.1 million live in the ocean.
Tropical rain forests on land and coral reefs in marine systems are among the most biologically diverse ecosystems on Earth and have become the focus of popular attention.
Amazon represents the quintessence of biodiversity, the richest ecosystem on earth.