I believe the biosphere is fragile, because over time all of the pollution us humans have made; If its from air pulloution, acid rain or even water pollution. the toxic acids over time have made the biosphere and the ozon layer weaker and more thin. which causes the biosphere to become weaker.
Integumentary system I believe
Answer:
aphthous ulcers
Explanation:
I took a medical course so i know :D
PS: thank and nark me brainly plzzz