The fight-or-flight response (also known as the acute stress response), refers to a physiological reaction that occurs when we are in the presence of something that is mentally or physically terrifying.
The fight-or-flight response is triggered by the release of hormones that prepare your body to either stay and deal with a threat or to run away to safety.
For example, you may yell at your partner for pushing you into agreeing to speak at a conference when you don't feel ready (fight).
The statement is once a year for women over 40 as they're more likely to develop breast cancer. Also it's once a year for all women over 18 with a family history of breast cancer as it is very rare to develop breast cancer as a child.