Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
The possible outcome would be a major disadvantage of any pain relief method that also affects awareness of the mother is that the mother may have difficulty working effectively with contractions.
Epidural :
The epidural is one of the most efficient ways to relieve pain during childbirth and delivery, and it has little side effects on both the mother and the newborn. During lengthy surgical operations, such as a C-section delivery, or while recovering from specific treatments, an epidural can offer continuous pain relief.
Some of the disadvantage of using pain relief :
- The blood pressure may drop suddenly after receiving an epidural.
- Shivering, fever, or itching are a few adverse symptoms that some women report.
- One can experience nausea or vertigo after having the epidural removed, along with back pain and soreness where the needle was inserted.
- With an epidural, some women report having more trouble giving birth. The likelihood of requiring interventions like forceps, drugs, or a C-section may rise significantly.
Learn more about childbirth here :
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Answer:
I’m not 100% sure but I believe it’s in your heart
Explanation:
Answer:
The human respiratory would have the most affect from the atmosphere
Explanation:
I Hope This HElps!!!!
