American settlers continue to spread to the west and took land from Native Americans. As expansion continued, agreements were signed and they were broken with native americans losing their homes and land and force to move west. As Native Americans were forced to more to the west, they are not able to adopt to the environment they are moving to, so they died due to lack of food or diseases.
The south— the north (mostly) opposed slavery, whereas the south (mostly) wanted to keep it around. In fact, slavery was one of the main reasons the American Civil War was fought in the first place.
They sparked an interest in new ideas. When the men left their hometown to go fight they learned many new cultures and even brought some traditions home. Therefore that also brought new ideas about how things work.