Answer:
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Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Air pressure (inside the lungs) is lowest when lung volume is highest, so the answer is B. when you breathe in your lungs expand, which makes the air molecules spread out, therefore the pressure is lower.
Answer:
roots spread out underground like the branches of a tree as to get sufficient water and nutrients form the soil to transport to the other parts of the tree for its own growth , by spreading out roots tend to collect or suck the maximum nutrients
If the reactants are the same the equations are balance but if the reactants are not the same you have to make them balance, however if the reactants are not balance in order to balance the equation you need to use coefficient to balance the reactants and products of particular chemical reaction.
yet for Photosynthesis the equation
CO_2 + H_2O => C_6H_12O_6 + H_2O + O_2
Find the ugliest Compound in equation and do not balance first the repetitive Element.
A)So the ugliest one is C_6H_12O_6 and the C is not repetitive and have six atoms so there fore we multiply 6 as coefficient with carbon dioxide.
6CO₂+ H₂O → C₆H₁₂O₆+H₂O+O₂ but oxygen will get 12 atoms because is to all Carbon dioxide.
B) Then we have carbon balanced then we are going to balance Hydrogen, yet on product side it have 14 but on the reactant side it have 2 but Oxygen on product side is 9 there but on reactant side we have 1 so there fore we have to multiply water on reactant side by 12 and on product side multiply water with six and in addition multiply oxygen with 6 which land you at:
6CO₂+ 12H₂O → C₆H₁₂O₆+6H₂O+6O₂.
so we will have 24 hydrogen and 24 oxygen on both sides.
Hope that helps you.
