The nullification crisis was a conflict between the U.S. state of South Carolina and the federal government of the United States in 1832–33. ... Calhoun, who opposed the federal imposition of the tariffs of 1828 and 1832 and argued that the U.S. Constitution gave states the right to block the enforcement of a federal law.
I’m not entirely sure, but since no one has answered yet, I’d go with C. It seems to relate most to what the Federalist and Democratic-Republicans disagreed on most.