Answer:
some signs may include, high fever, coughing, fatigue, muscle aching, and diarrhea.
The substrate of the citric acid cycle which can block respiration when it is present in excess is MALONATE. Malonate inhibits respiration by competing with succinate dehydrogenase for its acitve site. Malonate binds to the active site without reacting, thus competing with succinate. This disrupts the cellular respiration in the cell.
Tumor suppressor genes encode for proteins that inhibit or slow the progression of the cell cycle through a specific stage.they also encode for check point control proteins that arrests the cell cycle if the DNA is damaged or the chromosomes are abnormal. Mutation in the tumor suppressor genes that cause a loss or decreased function would lead to uncontrolled cell cycle leading to abnormal proliferation and the cell may become cancerous.
