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mote1985 [20]
3 years ago
13

How did Mendel’s experiments provide evidence for the principle of independent assortment?

Biology
2 answers:
ICE Princess25 [194]3 years ago
8 0

Answer:

Mendel formulated this principle after discovering another principle known as Mendel's law of segregation, both of which govern heredity. The law of independent assortment states that the alleles for a trait separate when gametes are formed. These allele pairs are then randomly united at fertilization.

Explanation:

Mendel discovered this principle after performing dihybrid crosses between plants that had two traits, such as seed color and pod color, that differed from one another. After these plants were allowed to self-pollinate, he noticed that the same ratio of 9:3:3:1 appeared among the offspring.

romanna [79]3 years ago
7 0
Mendel selected a group of dwarf plants and sel pollinated them by dusting mature pollen grains onto them. He then collected the resulting seeds and planted them and noticed these seeds germinated and grew into dwarf plants only.
He also selected tall plants and self-pollinated them. the resulting seeds he observed that they grew into a micture of tall and dwarf plants. He took the seeds of tall plants only and repeated the experiments for many generations until he obtained only tall plants.
He then crossed cross-pollinated purebreeds tall garden pea with pure breed variety. He planted the seeds and observed the offsprings were all tall plants. He crossed two of these tall offsprinf from the F1 and planted the resulting seeds. the second filial generation consisted of a mixture of tall and dwarf plants.
He counted these plants and noted that the ratio of tall to dwarf was about 3:1. From this, he postulated that there are now laws governing inheritance.The law of independent assortment and law of segregation.
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Explanation:

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ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein that is part of the T cell receptor, thereby it plays a critical role in T-cell signaling. When the TCR (receptor of T cells) is activated by the presentation of the specific antigen through the MHC, a protein called Lck acts to phosphorylate the intracellular CD3 chains and the ζ chains of the TCR complex, allowing the binding of the cytoplasmic tyrosine kinase, ZAP-70. Lck then phosphorylates and activates ZAP-70, which in turn phosphorylates another molecule in the signaling cascade called LAT (short for Linker of Activated T cells), a transmembrane protein that serves as an anchor site for several other proteins. The tyrosine phosphorylation cascade initiated by the Lck culminates in the intracellular mobilization of calcium ion (Ca2+) <u>and the activation of important signaling cascades within the lymphocytes.</u> These include the Ras-MEK-ERK pathway, which is based on activating certain transcription factors such as NFAT, NFκB and AP-1. These transcription factors regulate the production of of certain gene products, most notably cytokines such as interleukin-2 that promote the long-term proliferation and differentiation of activated lymphocytes.

The ITAM motifs (immunoreceptor tyrosine-based activation motif) are sequences of four amino acids present in the intracellular tails of certain proteins that serve as receptors within the immune system. Thus, <u>some receptors such as the TCR have ITAM sequences that, when activated, trigger an intracellular reaction based on consecutive phosphorylations</u>.  Kinases are recruited for this purpose.

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