I thinks it's Genetics. I might be wrong tho
Enzymes bind with chemical reactants called substrates. There may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. In some reactions, a single-reactant substrate is broken down into multiple products. ... The enzyme's active site binds to the substrate.
The water molecule slows down, meaning that it freezes because When water vapor in the atmosphere cools down, it will condense and change back into liquid water, forming clouds.