The four polysaccharides are glycogen, starch, cellulose, and chitlin. You consume them. They are sometimes artificially made or produced by your body.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
thermophile.
Explanation:
A thermophile is a kind of bacteria that belongs to the Archaea Domain and they are the kind of animals that can live in a region of high or extreme temperature. There has been a research on a kind of thermophile which is known as Methanopyrus kandleri which can exist in an extreme temperature of up to 500° C.
So, if we take a look at the question again we can see that after 48 hours and at 37°C 20,000 bacteria per milliliter are already in the tube and at more higher temperature of 55°C we have 1,568,000 bacteria per milliliter which means that at higher temperature more of the bacterial is produced.
