Question

S‑adenosylmethionine (abbreviated adoMet or SAM) is a methyl group donor in numerous metabolic pathways, including the metabolism of lipids and amino acids. Which of the following descriptions of S-adenosylmethionine are accurate?
A. The adenosyl group is linked to methionine via C4 and the β carbon of methionine.
B. The methyl group originally attached to the sulfur atom of methionine is transferred to an acceptor.
C. After ATP is cleaved, inorganic phosphate is added to C5 of the intermediate.
D. The transfer of the methyl group from adoMet to an acceptor yields S‑adenosylhomocysteine.
E. ATP is cleaved to PiPi and PPiPPi in adoMet synthesis.

Answer 1

Answer: Option D.

The transfer of the methyl group from adomet to an acceptor yields s adenosylhomocysteine.

Explanation:

S- adenosine methionine is a co substrate and one of the naturally occurring sulfonium ions in the body. It is synthesized from methionine which is abundant in animal derived protein. It is metabolised in the liver where it is converted to S adenosine methionine by the enzyme methionine adenosyltransferase. It involve the transfer of methyl group. It is use in medicine as alternative aid to reduce depression.