Answer:
1. Inhibiting IP3 channels, leading to decreased Ca2 in the sarcoplasm and reduced contraction.
2. Increasing the relative activity of MLCP, leading to a decrease in tension.
3. Activating K channels, increasing K leaking out of the cell which hyperpolarizes it and decreases the likelihood of Ca2 entry.
Explanation
In smooth muscle, cyclic AMP (cAMP) mediates relaxation because cAMP inhibits a specific kinase required for myosin light chain protein (MLCP) phosphorylation, thereby triggering contraction in the smooth muscles. It has been shown that cAMP inhibits 1,4,5-trisphosphate (IP3)-dependent calcium ions (Ca 2+) release by activation of the cGMP-dependent protein kinase (PKG). PKG proteins act to modulate Ca2+ oscillations by stimulating sarcoplasmic Ca2+-ATPase membrane proteins, increasing Ca2+ in the sarcoplasmic reticulum stores and Ca2+ efflux from the cells, and activate voltage-gated potassium (K) channels, thereby leading to membrane hyperpolarization and reducing Ca2+ entry through Ca2+ channels.
Each mouse in the study has brown ears.
They go to the brain then sent out to the rest of your body
1. Interphase is an important and the longest phase of the cell cycle during which the cell prepares for division by coping its DNA. It is metabolic phase of the cell, in which the cell grows, obtains nutrients and metabolizes them. There are three stages of interphase: G1 (the cell growth), S (replication of DNA, chromosomes are copied) and G2 (preparation for division). Without this phase, genetic material wouldn’t be ready for the process of meiosis and haploid gametes couldn’t be created.
2. Homologous chromosomes are the similar but not totally identical chromosome pairs that an organism receives from its two parents. During the prophase I of meiosis they pair up: each chromosome aligns with its homologue partner via link-chiasmata ( the two match up at corresponding positions). Those homologue pairs separate during a first stage of cell division (meiosis I-reduction of chromosomes number, from diploid to haploid), while sister chromatids separate during a second stage (meiosis II).
3. Crossing over is a process in which homologous chromosomes trade their parts. Crossing over is process of genetic recombination where DNA is cut and then repaired. Cut and repair of homologous chromosomes allow them to exchange some of their genetic information. As a consequence of crossing over, new arrangement of maternal and paternal alleles on the same chromosome is achieved. It is the way to create varations.
4. During the metaphase I, homologue pairs are lined up comparing to metaphase II where individual chromosomes are lined up. It is because during the meiosis I homologue pairs separate and chromosome number reduce from diploid to haploid. On the other hand, during the meiosis II, sister chromatids separate.
5. Nondisjunction is the consequence of cell division, where there is no properly separation. There are different forms of nondisjunction:
• failure of a pair of homologous chromosomes to separate in meiosis I,
• failure of sister chromatids to separate during meiosis II.
After nondisjunction, resulting daughter cells are with abnormal chromosome numbers -aneuploidy.
