Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
Learn more about receptors here:
brainly.com/question/11985070
#SPJ4
Answer:
A. will not change from generation to generation.
Explanation:
For a population in the Hardy-Weinberg equilibrium, allele frequencies do not change from generation to generation and remain constant. This occurs when:
-The population is large enough.
-Individuals of the population exhibit random mating
.
-No evolutionary force (natural selection, mutation, gene flow, etc.) is operative on the population.
Under these conditions, the allele frequencies of the population are not changed and the population is said to be in "Hardy-Weinberg equilibrium".
Answer:
Chloroplasts are what give plants their green color. The second major difference between plant and animal cells is the cell wall. While both plant and animal cells have a cell membrane, on plants have a cell wall.
Answer:
A, C, E
Explanation:
I got it right on edgenuity. This is the only parts that match the process of scientific inquiry.
