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alexandr1967 [171]
2 years ago
6

g protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation

Biology
1 answer:
Svetlanka [38]2 years ago
8 0

Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of  channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine  receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.

Learn more about receptors here:

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In those parts of equatorial Africa where the malaria parasite is most common, the sickle-cell allele constitutes 20% of the β h
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Answer:

gene flow

Explanation:

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Which inner planet is the largest?
kramer
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Attending to the size this is the increasing order: mercury, mars, venus and earth.

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Answer:

Any converging lens that has a small focal length (several centimeters) can be used as a magnifying glass. The observed object is placed in front of the magnifying glass so that it is located between the lens and the focus (closer to the focus).

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The observed object is placed between the magnifying glass and its focus (closer to the focus)

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When the character is most clearly seen, we can find ourselves on a given high species.

For a man with normal eyesight, it is about 25 cm.

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Answer:

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