1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
alexandr1967 [171]
1 year ago
6

g protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation

Biology
1 answer:
Svetlanka [38]1 year ago
8 0

Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of  channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine  receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.

Learn more about receptors here:

brainly.com/question/11985070

#SPJ4

You might be interested in
Why urination and ejaculation cannot go together?
MAXImum [283]
They are two very different tunings. Urination is basically releasing your urine while the other one relates to releasing sperm..
6 0
3 years ago
Read 2 more answers
Sample Response: The sound of the drumstick hitting the metal bar will get to me in a shorter amount of time in Scenario 1. The
maks197457 [2]

Answer:

The sound will reach my ear in a shorter time in Scenario 1.

The speed of sound waves in solids is faster than it is in gases.

Explanation:

The sound which is produce due to hitting of metal bar with a drumstick reaches to the ears in short time because sound is a longitudinal wave which requires or needs medium for its propagation from one place to another and in solids the particles of medium are close to each other as compared to air so the sound travels faster in solid materials as compared liquid and gases and takes less time to reach my ears.

7 0
3 years ago
By 1796 it had been observed that milk maids who had been exposed to cowpox did not succumb to the deadly plague of smallpox tha
xxTIMURxx [149]

Answer:

e.)  If exposure to cowpox gives immunity to smallpox in milkmaids, then milkmaids have a natural immunity and their blood should be used to develop a smallpox vaccine.

Explanation:

  • Milkmaids who suffered from cowpox did not suffer from smallpox i.e. they were immune to the disease.
  • If milkmaids did not suffer from smallpox then there must be some element of immunity that they received once they had recovered from cowpox, this would likely be found in their blood as antibodies.

6 0
3 years ago
You are dispatched to the scene of an assault with police on the scene. you arrive to find a​ 28-year-old female victim who rece
musickatia [10]
The correct option is this: HAVE YOUR PARTNER APPLY MANUAL STABILIZATION WHILE YOU APPLY A LOOSELY BANDAGED ABSORBENT DRESSING.
Stabilization is a process that is used to prevent shock in injured or sick people. Stabilization should be the first thing that is done for a patient when a patient is in shock. To manually stabilize a patient with neck injury; place your hands on both side of the person's head and do not attempt to align the head and the lower body. 
4 0
3 years ago
A mushroom's role in the ecosystem is as a
ehidna [41]
C. decomposer
C. from other organisms

6 0
3 years ago
Other questions:
  • According to the biological definition of a species, which organisms listed below would belong to the same species?
    14·2 answers
  • A cat is discovered with a very short tail. What would prove that this change was caused by a genetic mutation and not because t
    6·2 answers
  • Pretend you are writing in your field journal at the end of your stop in Tanzania. Be creative and write a paragraph describing
    8·1 answer
  • What are the characteristics of carbon bonds?
    5·1 answer
  • Which axis should be used to represent the dependent variable
    15·2 answers
  • On average how much energy is passed from one trophic level to the next
    7·1 answer
  • A type 1 diabetic male gives his wife an injection pen and asks her to inject him with its contents if he ever passes out due to
    9·1 answer
  • A team of science researchers is trying to decide which type of microscope to purchase for their laboratory. Compared to electro
    9·1 answer
  • PLEASE HELP
    13·2 answers
  • What is the scientific name of frog and man?​
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!