Explanation:
we are required to fill in the blank spaces in the attachment.
protein side chains are non polar. so the first answer is non polar. These side chains are hydrophobic in nature. so the second blank is hydrophobic. Non polar substances are known to have large number of van der waal forces. the third answer is large and the fourth is vanderwaals contact. the protein core destabilizes only when there is a weakening of vanderwaals contact which brings about mutation.
dear user your answer should look like this:
<u>Interactions of non polar side chains in protein sequence lead to the formation of a tightly packed hydrophobic core. This core is stabilized by a large number of vanderwaals contact. When a mutation occurs, it destabilizes the protein core and weakens vanderwaals contact leading to misfolding</u>
