Answer:
D. contact metamorphism
Explanation:
When there's a volcanic activity in certain area, very often it happens that there's magma that intrudes into the cold rock in the surrounding area. The intrusion of the hot magma into the cold rock layers causes big changes into the structure of the rocks. The high temperature and high pressure manage to influence the structure of the preexisting rocks, mostly on the places where the magma touches the cold rocks, leading to the formation of metamorphic rocks. This type of metamorphism is known as contact metamorphism.
<span>microtubules and microfilaments </span>
It depends on which forms they come in.
Answer:
Abstract
Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.
