The five principles that disrupt genetic equilibrium are
1) mutations in alleles
2) immigration and emigration
3) a small mating pool
4) natural selection occurs
5) Mating is not random
Answer;
Sister chromatids may drift apart after being synthesized.
Explanation;
-Cohesin is a protein which localizes between the sister chromatids and holds them together to resist the pull of the kinetochore microtubules.
-Because cohesin enables sister chromatids to remain attached from the time they are synthesized during S phase until the end of metaphase. If cohesin is defective, sister chromatids may separate before they normally would in anaphase, which would lead to daughter cells that have too few or too many chromosomes.
Alleles are versions of a gene that will express different qualities. Multiple alleles would mean that a gene has many variations; for example, there a multiple alleles for eye color: blue, green, brown, etc. The opposite would be a gene with just two variations; an example would be simple pea plants which can have smooth or wrinkled pods.
Hope this helps!!
Answer would be sarcoplasmic reticulum