Answer:
1. George O’Malley (Season 5, Episode 24)
The world collectively gasped when George was revealed to be on the other side of the elevator doors, dressed in his Army uniform, ready to guide Izzie (Katherine Heigl) to the afterlife. This intense Season 5 ending was the audience’s first time witnessing the death of a main circle doctor, forever raising the stakes to come. From Callie recognizing the freckle, to John Doe tracing “007” into Meredith’s palm, each moment created goosebumps. The underdog of the interns didn’t deserve to go out being dragged under a bus, but it’s only fitting that he did it to save someone else’s life.
2. Denny Duquette (Season 2, Episode 27)
Love makes people do crazy things; but, unfortunately cutting L-Vad wires, breaking the law, and Izzie almost losing her job couldn’t save Denny Duquette from death. Isabel and Denny’s love story was the first flame that could’ve shone brighter than Meredith and Derek’s. It’s largely why the death of Denny was so heartbreakingly tragic. Although Izzie seemed to move on, Denny’s ghostly cameo in Season 5 made it clear the love story was always doomed.
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