Answer:
When the pKa is 6.0, we can determine the fraction of protonated H is by:
pH = pKa + log [A]/[HA]
Where
A = Deprotonated imidazole side
HA = Protonated side
Given, pH = 5.0
5 = 6 + log [A]/[HA]
log [A]/[HA] = -1 (take antilog of both side)
[A]/[HA] = 0.1
The ratio of the deprotonated imidazole side chain to the protonated side chain at pH 5.0 = 0.1
Given, pH = 7.5
7.5 = 6 + log [A]/[HA]
log [A]/[HA] = 1.5 (take antilog of both sides)
[A]/[HA] = 31.62
The ratio of the deprotonated imidazole side chain to the protonated side chain at pH 5.0 = 31.62
Prader-Willi syndrome (PWS) is a gentic disorder which has an impact on numerous physiological systems. PWS affected individuals (specifically babies) experience delayed growth, significant hypotonia (low muscle tone), and feeding issues. It does effect circadian rhythms in mice models.
SNORD116, often referred to as HBII-85, is a non-coding RNA (ncRNA) molecule that contributes to the alteration of other small nuclear RNAs (snRNAs). Unlike the majority of other snoRNAs, SNORD116 is not significantly complementary to ribosomal RNA and is expressed widely in the brain (but not in PWS patients).
According to the studies, SNORD116 cause sleep defect in patients with Prader-Willi syndrome. Same observation was seen in mouse models too. Paternal expression of SNORD116 is thought to be a potential gene for the sleep disruptions/circadian rhythm’s that the majority of PWS sufferers.
To learn more about circadian rhythm click here
brainly.com/question/6434404
#SPJ4
Listed under are the 5 different type of cells found in the epidermis and their description:
1. Stem cells
These are what you call undifferentiated cells. These are cells found in the stratum basale, which is the deapest layer of the epidermis. These cells divide to create keratinocytes.
2. Keratinocytes
The make up the majority of the cells in the epidermis. They synthesize keratin which are proteins that make up your hair, skin, and nails. They can also be found in other organs inside your body.
3. Melanocytes
These cells can only be found in the stratum basale. They synthesize melanin with a brown to black pigment. These dark pigments serves as protection for the skin from harmful UV rays.
4.Merkel cells
Merkel cells are also known as <em>tactile cells</em>. They are the sensory receptor for touch. Merkel cells and the nerve fiber together are called the Merkel disc.
5. Dentritic cells
They are also known as <em>Langerhans cells</em>. They can be found in two layers of the epidermis: the stratum spinosm; and stratum granulosm. They are what you call macrophages that come from the bone marrow. They serve as immune cells that provide protection against toxins, microbes and other pathogens that try to penetrate the skin.
Hope you find some information above that will help you.
Worms don't have lungs. They breathe through their skin.
Hope this helps. :)
