Answer: option B) Secretin
Explanation:
Secretin is an enzyme formed by the upper intestinal layer and gets transported by blood to the PANCREAS which it stimulates: causing the flow of pancreatic juice, also the flow of bile and intestinal juice but to a lesser extent.
Alongside Gastrin, Secretin is one of the hormones of the Gastrointestinal tract; but their functions differ
Therefore, Secretin is the answer
Answer:
Concentration gradient
Explanation:
Concentration gradient of the ions across the membrane generates the membrane resting potential.
Concentration gradient means that there is unequal distribution of the ions on different sides of membrane. For example, the concentration of K ions is much higher within the cell then out of the cell. Opposite is with the Na ions. When ions move from the area of their higher concentration to the are with the lower concentration, we say they move down the gradient or diffuse (no energy required). On the other hand, movement of ions against their gradient means that this process requires energy and involves protein pumps.
Human monoclonal antibody (mAbs) are emerging in the field of cancer therapy and have become an increasing proportion of new drugs that are recently approved. Although there are some methods to obtain antigen-specific mAbs from human B cells, it is generally impossible to directly immunize human beings with antigens of interest. For example, for infectious agents, those approaches are largely restricted. To solve these obstacles, two main approaches have been developed; either by humanizing antigen-specific antibodies from small experimental animals (which is laborious due to the great genetic differences from humans) or rely on the in vitro selection of antigen-specific binders from human antibody repertoires. However, the human mAbs developed by these methods are usually with low affinity.
We are now coming up with a much better idea that is humanizing non-human primates mAbs instead of murine mAbs. Due to the close genetic relationship with humans, immunized NHPs have more potential to be isolated with high affinity antibody to human target than other experimental species, such as mouse, rat and rabbit. In addition, with appropriate method, NHP antibodies are much<span> easier to be humanized</span> without any loss of affinity compared to widely used murine antibodies.
Resource: http://www.creative-biolabs.com/High-Affi-TM-Human-Antibody-Discovery.html
