Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
A product which contains magnesium and an amino acid, L-theanine as key ingredients.
- Magnesium included in the dietary supplement is A vitamin and is need for health.
Magnesium is a mineral that contributes to proper body functioning and proper sleep. Our body can't make Magnesium, so we need to take it from our diet.
For more information on magnesium, visit
brainly.com/subject/chemistry
Answer:
A 12-year-old boy with a history of type 1 diabetes was brought to the ER because most probably he was experiencing diabetic ketoacidosis, which is a complication of type 1 diabetes.
It is a condition where the body does not produce enough insulin, or the insulin that is produced does not work well.
Explanation:
DKA is caused by too many ketones being released into the bloodstream, which causes the blood to become acidic.
The vomiting, headache, becoming increasingly lethargic dehydration and breathlessness are the symptoms of DKA.
High blood sugar levels and ketones in his urine are the signs of DKA. DKA is a complication of type 1 diabetes, and it can be fatal. It is caused by high blood sugar levels and dehydration.
#SPJ4
brainly.com/app/ask?q=Type+I+DM
Answer:
Well yeah but only if you're bad
at taking pills lol
Answer:
False
Explanation:
Seizures are caused by a number of factors that don't include epilepsy.
