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I have a feeling it's when they are embryos.
Food chain. Think of a food chain as a series of links side by side, and a food web as a large spider web connecting at multiple points.
Goes through:
<span>Mouth
Esophagus
Stomach
The small intestine
Colon (large intestine)
<span>Rectum</span></span>
I did research but I couldn't find the exact answer but those are some websites maybe they could help you. I am sorry I did my best to help.
https://www.healthline.com/health/sickle-cell-anemia#outlook
http://sickle.bwh.harvard.edu/scd_inheritance.html
I hope those 2 websites help