Answer and explanation:
Fungi and protists are eukaryotic. However, antibiotics selectively targets prokaryotic cells. Thus, the use of antibiotics for the treatment of fungal and protist infection is of no use at the first place. Secondly, if we use the other medicines that could kill the fungi/protists (e.g. fungicides), they could also kill the host's cells (animal's cells). This become further difficult if the infection is deeper in the skin. This is because, we would not be able to apply the medicine as direct application on skin but would give either intravenous or via food. This would increase the chance of imacting negatively the other organs/cells. The only option in such scenario is the surgery, which cannot be 100% effective because some spores may left even after the treatment.
I believe that would be small polar and nonpolar molecules.
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Biologists recognize five levels of cell organization. The lowest and simplest is the cellular level. Organisms here are either unicellular organisms, like protozoa, or colonial organisms. Colonial organisms are composed of single-celled individuals that stay together to sustain the life of the whole colony. Next on the scale of complexity is the level occupied by tissue. A tissue is a group of similar cells that perform a similar activity. Tissues that are organized around a common function together make up an organ, the third level of complexity. The fourth level of organization is the system, formed by a group of organs that together perform a specific bodily process. The fifth and highest level is the organism level, in which body systems work together in a structure capable of independent life.