Answer:
Option (2).
Explanation:
The cell potential or membrane potential may be defined as the difference in the electric potential between inside and outside of the cell. The membrane potential of the cell changes during the propagation of action potential.
The resting membrane potential is -70mV. The influx of sodium ions causes the depolarization of the cell membrane. The cell potential changes from -70mV to + 30mV. The membrane potential becomes more positive during the depolarization phase.
Thus, the correct answer is option (2).
Answer:
They become stronger due to the bones slowly growing together and forming newer longer bones
Explanation:
Answer:
Mike ghost hunting glitchy jumbo doctor
Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
