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AleksAgata [21]
3 years ago
11

4.6 Fusion of the reading frames of the bcr and abl genes, as is often observed in cases of chronic myelogenous leukemia (CML),

is an example of what type of genetic alteration
Biology
1 answer:
kirill115 [55]3 years ago
4 0

Answer:

The answer is reciprocal chromosomal translocation

Explanation:

The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.

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Answer:

Ecosystem.

Explanation:

Ecosystem is not a contributing factor to ecosystem stability whereas, species, genetic, and abiotic diversity are the factors that contributes in the stability of an ecosystem. The diversity of species greatly affected the ecosystem stability if more species are present in he ecosystem. The abiotic factors also plays an important role in the stability of an ecosystem because these abiotic factors causes changes in the ecosystem environmental conditions.

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3. What is crossing over? When does it occur during meiosis? Why did you have difficulty modeling this element of meiosis using
FrozenT [24]
Crossing over happens in Meiosis 1 only. In Prophase 1 a cells chromatin (chromatin = chromosomes that have not condensed yet) condense and pair up forming homologous chromosomes (paired = XX (2 chromosomes together)). When this happens segments/ alleles of the chromosomes pairing up swap over. This creates genetic diversity as each chromosome is different, it has parts from its pair. This leaves every chromosome unique and individual.

I hope this helps, sorry some of the vocab is rather technical. By the way I would suggest watching the 'Crash Course: Meiosis' on YouTube, this really helped me when I was learning this topic. :D 

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3 years ago
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What is agricultural monoculture and why is that bad for crops?
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<h2>EXPLANATION:</h2>

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3 years ago
O QUE É UM CLONE? EXPLIQUE COMO OCORRE A CLONAGEM EM MAMÍFEROS.
Pavlova-9 [17]

Answer:

A clonagem é a obtenção de duas células idênticas com o mesmo código genético que o produto da reprodução assexuada.

Nos mamíferos, a clonagem ocorre através de células somáticas, onde há um núcleo doador e um oócito que se unem por meio de um choque elétrico, formando o embrião que resultará em um ser vivo clonado, um exemplo de essa era Dolly, a ovelha.

Explanation:

Na clonagem de mamíferos, o embrião é responsável por ter caracteres da ovelha doadora, ou seja, será a imitação do código genético desse animal que empresta a célula doadora ao úbere.

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