1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
AleksAgata [21]
3 years ago
11

4.6 Fusion of the reading frames of the bcr and abl genes, as is often observed in cases of chronic myelogenous leukemia (CML),

is an example of what type of genetic alteration
Biology
1 answer:
kirill115 [55]3 years ago
4 0

Answer:

The answer is reciprocal chromosomal translocation

Explanation:

The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.

You might be interested in
What type of chromosomal abnormality can lead to multiple copies of a gene, some of which can incur mutations that can lead to t
koban [17]

A trisomy is a chromosomal condition characterized by an additional chromosome. A person with a trisomy has 47 chromosomes instead of 46.

Trisomy means the presence of an extra chromosome in some or all of the body's cells. This results in a total of three copies of that chromosome instead of the normal two copies. For example, Down syndrome (trisomy 21) is caused by having three copies of chromosome 21 instead of the usual two copies.

This genetic condition is the result of a genetic mutation where your cells don't divide as they should. You can't prevent this abnormality from happening during cell division.

To learn more about trisomy here

brainly.com/question/15114915

#SPJ4

4 0
2 years ago
DNA is a complex biological polymer called a
Paul [167]
DNA is an example of a complex biological polymer called a nuclei acid. Nucleic acids are made up of many smaller sub units called nucleotides.  The components of a DNA nucleotide are deoxyribose, phosphate group, nitrogen group. There are four possible bases in a DNA molecules which includes adenine, cytosine, guanine and tymine. 
7 0
3 years ago
Macronutrients are nutrients that contain inorganic components. <br> a. True <br> b. False
emmasim [6.3K]
This is false, as macronutrients are all made of organic components. Macronutrients are carbohydrates, fats, and proteins. The most basic unit for carbohydrates is glucose. Glucose is an organic molecule with a chemical formula of C6H12O6 which then is broken down by the body to convert it to energy (in the form of ATP). Fats or triglycerides are comprised of fatty acids and a glycerol backbone which can also be used by the body for energy or can be stored for later use. Proteins on the other hand are functional molecules wherein the basic unit for proteins is the amino acid. Proteins are exemplified because they contain nitrogen (CHON). All of which can be used as energy and has specific caloric value per gram (4 kcal for every gram of protein and carbohydrates and 9 kcal for every gram of fat).

Micronutrients are usually inorganic compounds with no caloric value. Usually these micronutrients are essential for maintaining biochemical pathways in the body. For instance, niacin and riboflavin are vitamins that are needed in the production of NAD and FAD which are important for reduction-oxidation reactions in the body (i.e. tricarboxylic acid cycle and electron transport chain).
6 0
3 years ago
A geneticist isolates a new restriction enzyme from the bacterium Aeromonas ranidae. No other restriction enzymes have been isol
Shalnov [3]

Answer:

AraI

Explanation:

<em><u>A</u></em><em>eromonas </em><em><u>ra</u></em><em>nidae</em> <u>I</u> (first enzyme isolated in that bacterium)

7 0
3 years ago
Name the cranial nerve responsible for the following:
DedPeter [7]
 the answer is the facial nerve
6 0
3 years ago
Other questions:
  • What is the physiological explanation for the negative effects of prolonged stress on health? Talk about stress hormones.
    5·1 answer
  • Racial segregation and exclusion are most likely to be eliminated in sports when
    8·1 answer
  • Cat claim and defend certain
    6·2 answers
  • What is the importance of the light and dark reactions in photosynthesis?
    10·1 answer
  • What % of living things have a range of tolerance
    13·1 answer
  • How many atoms are in something dermines it’s
    14·1 answer
  • Question 6 Pls answer its 20 point
    13·1 answer
  • Will give brainliest!! Make a claim for how the cell cycle relates to the growth and maintenance of organisms. Discuss the stage
    11·1 answer
  • What causes the most destruction from earthquakes?
    14·2 answers
  • Which gland is named for a nearby prominent cartilage?.
    15·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!