PD linked mutation may cause neurodegeneration via different mechanism.
<h3>What is Novel Parkinson's disease linked mutation ?</h3>
A novel mutation in the α-Synuclein (α-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy (MSA)
- the G51D mutation significantly attenuates α-Syn aggregation in vitro.
- it disrupts local helix formation in the presence of SDS, decreases binding to lipid vesicles C-terminal to the site of mutation and severely inhibits helical folding in the presence of acidic vesicles.
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Answer:
The transition state is the state that has highest activation energy as compared with the reactant or product. Intermediate state is important for the conversion of the reactant into the product. Transition state analogue may be any molecule that has similar feature with the transition state.
The intermediate state has the finite life time greater than the 10⁻¹³s.They can be detected easily as well as stable. Intermediate stages include the enzyme substrate complex or enzyme product complex. Transition state analogue mimic the transition state and can also acts as inhibitor. The transition state shows highest energy and o not have fix life time. The incomplete broken bonds and incomplete formed bonds are present in the transition state.
D. This is because convection is the process of heat passing through liquid or gas.
The most significant uses of coal are in electricity generation, steel production, cement manufacturing and as a liquid fuel. Steam coal - also known as thermal coal - is mainly used in power generation.