Vacuole is a space that is line with membrane and within the cell that lacks cytoplasm but filled with fluid.
They are important cytoplasmic organelles and perform certain functions such as storage, ingestion, digestion, excretion, and expulsion of excess water.
In plant, large central vacuoles enable them to attain a large size without accumulating the bulk that would make metabolism difficult.
Antibiotic resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow. Infections caused by antibiotic-resistant germs are difficult, and sometimes impossible, to treat.
Natural selection is based on Darwin’s observation that individuals most likely to survive and reproduce are those with traits best suited to their current environment.