A new DNA strand elongate only in the 5' to 3' direction during DNA replication because the "polarity of the DNA molecule prevents addition of nucleotides at the 3' end" .
DNA replication occurs in the 5' to 3' direction. DNA polymerase can only add nucleotides to the 3' OH group of the growing DNA strand, this is why DNA replication occurs only in the 5' to 3' direction.
DNA polymerase can only add to the 3' end, so the 5' end of the primer remains unaltered. Consequently, synthesis proceeds immediately only along the so-called leading strand.
Hence, the correct answer will be option (B)
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Answer:
It recognizes and binds to a pair of "mismatched" nucleotides, preventing their translation.
Explanation:
Mut L protein is involved in mismatch DNA repair. MutL protein is complexed with MutS protein and the MutL-MutS complex recognizes all the mismatched base pairs present in the newly formed DNA strand. The complex can not recognize the "C-C" pairs. MutH protein joins the complex.
The MutH protein also has a site-specific endonuclease activity and cleaves the unmethylated DNA strand towards the 5' end of the guanine base in the GATC sequence to mark the strand for DNA repair. In this way, MutL protein, along with MutS and MutH proteins mark the mismatched DNA bases for repair so that they are not translated into a faulty protein.
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