Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer;
-Kinetic energy
Explanation;
The energy associated with motion or movement is called kinetic energy.
-Kinetic and potential energies are found in all objects. If an object is moving, it is said to have kinetic energy (KE). Potential energy is stored energy and the energy of position; gravitational energy.
-An object that has motion - whether it is vertical or horizontal motion - has kinetic energy. Kinetic energy is calculated by the formula 1/2mv², where m is the mass of the object and v is the velocity of the object.
-Therefore, kinetic energy depends upon two variables: the mass (m) of the object and the speed (v) of the object.
Answer: See attached picture.
Explanation:
DNA or deoxyribonucleic acid is the name for the molecule that contains the genetic information in all living things. This molecule consists of two strands that wind around each other to form a double helix structure.
The basic unit of nucleic acids are called nucleotides, which are organic molecules formed by the covalent bonding of a nucleoside (a pentose which is a type of sugar and a nitrogenous base) and a phosphate group. So each nucleotide is made up of a pentose sugar called deoxyribose, a nitrogenous base which can be adenine (A), thymine (T), cytosine (C) or guanine (G) and a phosphate group.
<u>What distinguishes one polynucleotide from another is the nitrogenous base</u>, and thus the sequence of DNA is specified by naming only the sequence of its bases. The sequential arrangement of these four bases along the chain is what encodes the genetic information, following the following criterion of complementarity: A-T and G-C. So the sequence of these bases along the chain is what encodes the instructions for forming proteins and RNA molecules. In living organisms, DNA occurs as a double strand of nucleotides, in which the two strands are linked together by connections called hydrogen bridges.
The chemical convention of naming the carbon atoms in the pentose nucleotide pentose numerically confers the names 5' end and 3' end ("five prime end" and "three prime end" respectively). The 5'-end designates the end of a DNA strand that coincides with the phosphate group of the fifth carbon of the respective terminal deoxyribose. A phosphate group attached to the 5'-end allows the ligation of two nucleotides; for example, the covalent bonding of the 5'-phosphate group to the 3'-hydroxyl group of another nucleotide, to form a phosphodiester bond.
wrecking crew: old building:: lysosome: damaged organelle.
A lysosome is an organelle that contains enzymes that break down and digest unneeded cellular components, such as a damaged organelle.
