Answer
:When thermal energy is added to a substance, its temperature increases, which can change its state from solid to liquid (melting), liquid to gas (vaporization), or solid to gas (sublimation). ... When the pressure exerted on a substance increases, it can cause the substance to condense.
The answer would be translation :)
Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
The jelly-like fluid that fills a cell is calledcytoplasm<span>. It is made up of mostly water and salt. </span>Cytoplasm is present within the cell membrane of all cell types and contains all organelles and cell parts.<span>Cytoplasm has various functions in the cell. </span>
Most of the important activities of the cell occur in the cytoplasm. Cytoplasm contains molecules such as enzymes which are responsible for breaking down waste and also aid in metabolic activity.
<span>Cytoplasm is responsible for giving a cell its shape. It helps to fill out the cell and keeps organelles in their place. Without cytoplasm, the cell would be deflated and materials would not be able to pass easily from one organelle to another.</span>
