Ribosomes are small particles of RNA and protein which are found throughout the cytoplasm in all cells; they produce proteins by following coded instructions from DNA. They produce proteins through coded instructions that come from the nucleus of a cell.
A substrate fits into the active site of an enzyme like a lock and key. The substrate has a certain shape that matches or is very similar to the shape of the enzyme so it's the perfect fit, like "a lock and key."
Answer: Its is the second one.