Prophase is the first step in mitosis and many changes occur. Chromatin fibers become coiled into chromosomes, with each chromosome having 2 chromatids joined at a centromere. The mitosis spindle, composed of microtubules and proteins, form in the cytoplasm.
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Griffith concluded that the R-strain bacteria must have taken up what he called a "transforming principle" from the heat-killed S bacteria, which allowed them to "transform" into smooth-coated bacteria and become virulent.
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prokaryotic are unicellular organisms
eukaryotic are multicellular
Prokaryotic need only one parent to reproduce
Eukaryotic need 2 parents to reproduce
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