Answer:
One of the common genetic disorders is sickle cell anemia, in which 2 recessive alleles must meet to allow for destruction and alteration in the morphology of red blood cells. This usually leads to loss of proper binding of oxygen to hemoglobin and curved, sickle-shaped erythrocytes. The mutation causing this disease occurs in the 6th codon of the HBB gene encoding the hemoglobin subunit β (β-globin), a protein, serving as an integral part of the adult hemoglobin A (HbA), which is a heterotetramer of 2 α chains and 2 β chains that is responsible for binding to the oxygen in the blood. This mutation changes a charged glutamic acid to a hydrophobic valine residue and disrupts the tertiary structure and stability of the hemoglobin molecule. Since in the field of protein intrinsic disorder, charged and polar residues are typically considered as disorder promoting, in opposite to the order-promoting non-polar hydrophobic residues, in this study we attempted to answer a question if intrinsic disorder might have a role in the pathogenesis of sickle cell anemia. To this end, several disorder predictors were utilized to evaluate the presence of intrinsically disordered regions in all subunits of human hemoglobin: α, β, δ, ε, ζ, γ1, and γ2. Then, structural analysis was completed by using the SWISS-MODEL Repository to visualize the outputs of the disorder predictors. Finally, Uniprot STRING and D2P2 were used to determine biochemical interactome and protein partners for each hemoglobin subunit along with analyzing their posttranslational modifications. All these properties were used to determine any differences between the 6 different types of subunits of hemoglobin and to correlate the mutation leading to sickle cell anemia with intrinsic disorder propensity.
Explanation:
The process of when a lake freezes in the winter and thaws in the spring without changing the size or shape is neither constructive or destructive! It's neither.
Answer:a positive feedback
Explanation: positive feedback is a type of feedback mechanism employed by the body,in which an output is enhanced or acclerated.
In contrast to negative feedback where the body regulates it's internal conditions by reducing the effect of a stimuli,In positive feedback ,the body enhances the effect of the stimuli.
It is not common as negative feedback in homeostasis.
An example is the increasing release of oxytocin to promote contractions during childbirth,until the child is born.
Another example is the accumulation of blood platelet , in the site of blood vessels injury to
cause blood clotting.
brainly.com/question/8665721
Answer: What stage of succession is taking place in the forest?
The first stage of forest succession is the grass, or plant stage, which occurs after land has been cleared due to natural events or otherwise. The sudden clearing floods the ground with sunlight; very shade-intolerant pioneer species like longleaf pine, aspen, or cottonwood begin to compete with grasses.
What three major processes contribute to succession?
Causes of succession
Three major causes have been identified for the process of succession. a. Initiating causes - These include biotic and climatic factors which destroy the existing populations of the area. Climatic factors include wind, fire, natural disasters, erosionWhat are the 4 stages of succession?
There are five main elements to ecological succession: primary succession, secondary succession, pioneer and niche species, climax communities and sub-climax communities.
Primary Succession. ...
Secondary Succession. ...
Pioneer and Niche Species. ...
Climax Communities. ...
Sub-climax Communities.
Puberty is defined as the physical changes that occur in the
body as sexual development is stimulated by hormonal changes. Through puberty,
a child's body undergoes the process maturity into that of an adult, who is capable
of sexual reproductive functions.
