Some proteins do indeed need assistance during the folding process. the general term used for the proteins that help other proteins fold is Chaperones.
<h3>What are Chaperones?</h3>
- Chaperones are proteins that help big proteins or macromolecular protein complexes fold or unfold conformationally. There are different groups of molecular chaperones, all of which have the same purpose: to help big proteins fold properly during or after synthesis as well as following partial denaturation.
- Protein translocation for proteolysis involves chaperones as well. The bulk of molecular chaperones aid in protein folding by binding to and stabilizing folding intermediates up until the polypeptide chain is entirely translated, rather than providing any steric information for protein folding.
- Based on their target proteins and location, chaperones have different unique modes of operation.
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Answer:
The two main reasons are nonpolar core of the bilayer and the active transport.
Explanation:
The membrane is structured to have two outer layers that are polar and an inner layer that is nonpolar.
If a membrane protein is exposed to the solvent, i<em>t will also have a polar side. It would be very difficult for the polar face of the membrane to move through the nonpolar core of the bilayer.</em> Therefore, this model is not feasible.
One major form of transport, active transport, moves solutes up the concentration gradient. <em>The binding of a solute and then release on another side of the membrane would only work for facilitated diffusion because it would cause a net movement of solutes down the concentration gradient.</em> It is unclear how energy could be expended to drive this process in the transverse carrier model.<em> Therefore, the transverse carrier model does not explain active transport.</em>
Mutations can lead to changes in the structure of an encoded protein or to a decrease or complete loss in its expression. Because a change in the DNA sequence affects all copies of the encoded protein, mutations can be particularly damaging to a cell or organism.
An element's atomic number is the amount of protons (positively charge subatomic particle found in the atoms nucleus) present in one atom of that element.
<span>The proportion of dissolved salts to pure water in the ocean is known as salinity. This is commonly measured in parts per thousand. For example, if the salinity of an ocean is 35 parts per thousand, or ppt, this means that in every kilogram, or 1000 grams, of ocean water, there are 35 grams of salt present. The higher the quantity of parts per thousand, the saltier the water, which also means the higher the salinity.</span>
