Answer:
Potential targets:
1- DNA methyltransferases
2- Chromatin modifiers such as histone acetyltransferases, histone deacetylases, histone methyltransferases, etc.
3- Components of the RNA interference (RNAi) machinery such as Dicer, Argonaute, etc.
Explanation:
Epigenetics can be defined as the study of any heritable change in the phenotype that does not involve modifications in the DNA sequence. Epigenetic mechanisms can be classified into three major types: 1-DNA methylation, 2-histone modifications (e.g., acetylation, methylation, phosphorylation, etc), and 3-regulatory non-coding RNAs (e.g., miRNAs, lncRNAs, siRNAs, etc) that modulate target gene expression via the RNA interference pathway. There are different types of proteins that are involved in these complex epigenetic mechanisms, and those cited above represent only some examples that can be used as therapeutic targets.
A subsurface rock layer that is composed of clay and bedrock and is an impermeable barrier to water flow would be described as a(n) <u>aquifer(option b)</u>.
An aquifer is an underground layer of water-bearing permeable rock, rock fractures or unconsolidated materials (gravel, sand, or silt).
The study of water flow in aquifers and the characterization of aquifers is called hydrogeology. Aquifers occur from near-surface to deeper than 9,000 metres (30,000 ft).
There are three different types of aquifers: confined, unconfined, and perched. Recharge zones are typically at higher altitudes but can occur wherever water enters an aquifer, such as from rain, snowmelt, river and reservoir leakage, or from irrigation.
To learn more about aquifers, here
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