Answer:
Equal amounts of DNA contain equal proportions of nitrogenous bases.
Explanation:
According to Chargaff's rule, the nitrogenous base pairs (Purines and pyrimidines) have an equal ratio (1:1) in the DNA of all the organisms. More precisely, the amount of adenine is equal to thymine and the amount of guanine is equal to cytosine in the DNA of all the organism. A-T base pair has two H-bonds while G-C base pair has three H-bonds.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
herbivore-those kinds of animals that eat plants and trees only e.g elephants
omnivore-those animals that eat both meat and plants e.g baboons /humans
carnivore-those animals that eat meat only some call them the preditors e.g lions /cheetah
Answer:
A. Robin A will have an easier time finding a mate.
Explanation:
He will have an easier time since he have more songs, which the females find attractive.
