1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Jet001 [13]
2 years ago
13

Pyruvate dehydrogenase deficiency is a genetic disease most commonly linked to a mutation in the a -subunit of the mitochondrial

enzyme that causes the enzyme to cease functioning. As a result of the mutation, affected individuals build up dangerous amounts of lactic acid. Which of the following best explains the buildup of lactic acid in individuals with the mutation?
a. Cells use lactic acid to shunt electrons from pyruvate to the electron transport chain in the mitochondria.
b. Cells undergo glycolysis because there is a buildup of pyruvate in affected individuals.
c. Cells cannot transport pyruvate to the mitochondria in the absence of pyruvate dehydrogenase activity, so the pyruvate is broken down to lactic acid and ethanol
d. Cells undergo fermentation because pyruvate cannot be metabolized to proceed into the Krebs cycle.
Biology
1 answer:
zlopas [31]2 years ago
6 0

Answer: The correct option is D ( Cells undergo fermentation because pyruvate cannot be metabolized to proceed into the Krebs cycle).

Explanation:

Pyruvate dehydrogenase is the enzyme that converts pyruvate to acetyl CoA which enters the Krebs cycle in glucose metabolism. The deficiency of Pyruvate dehydrogenase can be caused by genetic origin most commonly linked to a mutation in the a -subunit of the mitochondrial enzyme that causes the enzyme to cease functioning. As a result of the mutation, affected individuals build up dangerous amounts of lactic acid.

The increase in the level of lactic acid occurs due to the Increased action of lactate dehydrogenase enzyme. In the absence of Pyruvate dehydrogenase enzyme, the level of blood pyruvate increases. Excess pyruvate is then converted to lactic acid by lactate dehydrogenase enzyme in a process called lactic fermentation. This results in a buildup of lactic acid in the blood leading to a condition called lactic acidosis .

Therefore, cells undergo fermentation because pyruvate cannot be metabolized to proceed into the Krebs cycle.

You might be interested in
Weathering is a _____ force since it naturally breaks rock down into sediment.
svetlana [45]

Answer: C

Explanation:

5 0
3 years ago
Over time, what will happen to the population of brown mice that live in a
Sunny_sXe [5.5K]

Answer:

The population will decrease

Explanation:

The reason it will decrease is that the predators will be able to find the brown mice more easily in the snow then the white mice.

7 0
3 years ago
A human zygote is produced from two gametes that are identical in________
Cerrena [4.2K]

Answer:

C

Hope its helps

Correct me if im wrong

6 0
2 years ago
Describe the process of natural selection
Keith_Richards [23]
Natural selection is the process in which the more favorable traits due to mutation that are in a select few in a population produce more offspring then others. An example of this is bacteria resistant to antibiotics due to the faster reproduction of the resistant bacteria over the non resistant ones
3 0
3 years ago
Read 2 more answers
What usually drives animal research is the benefit to human beings of that research?
svlad2 [7]

Answer:

i dont understand what do you mean. theres a spelling mistake

Explanation:

8 0
3 years ago
Read 2 more answers
Other questions:
  • This type of reproduction in plants is centered around the flower's ovum
    6·1 answer
  • Linnaeus is considered the "Father of _____." a.Modern Taxonomy B.Botany c.Zoology
    10·2 answers
  • 1, based on what you know about blood, why would having a sickle cell anemia crisis result in a reduced red blood cell count, an
    6·1 answer
  • 98 POINTS
    9·2 answers
  • Every reaction in a cell requires a specific enzyme.
    5·1 answer
  • Which process moves water molecules across the membrane of a cell?
    11·2 answers
  • Biology help pleaseeeeee
    12·2 answers
  • In about 90% of cases, Huntington’s disease is inherited. But in 10% of cases, there is no evidence that a parent has the diseas
    15·2 answers
  • Are amplitude and wavelength related
    14·1 answer
  • Ibuprofen is a drug commonly used to relve inflammation and pain, it is a mixture of two enatiomes whicha re moldules that:_____
    5·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!