Answer:
Is characteristic of Diabetes.
Explanation:
Diabetes is a disorder in which blood sugar increases due to the fact that there is mechanism by which sugar enters the cell is somehow affected.
There are different types of this disorder, the most common ones are the following,
1. Diabetes type 1, is an autoimmune disorder in which the cells that are in charge of producing insulin are destroyed, as a consequence there is not enough insulin (responsible for allowing the glucose channels to open and transport glucose into the cell). Therefore, sugar remains in blood circulation. When glucose levels are too high, it starts filtering through the kidneys and ends up in the urine.
2. Diabetes type 2, is triggered by different factors, there are genetic and environmental factors that trigger this disease. In this case, cells are 'resistant' to the insulin effect, so the body reacts by secreting more insulin. As a consequence, cells in charge of secreting insulin are overworked and at the same time, the body cells keep on increasing the resistance to insulin. There is a point in which this compensation fails to work, and blood sugar rises. When the levels become high, glucose starts filtering through the kidneys and ends up in the urine.
There are more types of diabetes, such as gestational diabetes or LADA. In this cases the cause of the disease varies, but the outcome is the same, increased blood glucose levels and presence of glucose in the urine.
Answer:
Explanation:
Two disadvantages of using the DSM are, it oversimplifies human behivior and increses the risk of misdiagnosis. That negatively impacts individuals becuase (you didnt put anything here so just add your answer ig)
hope this helped!
Answer:
Dental administrator assistant duties typically involve managing medical records, accounts receivable, and reimbursement, as well as billing patients and insurance, scheduling patients, and performing procedural and diagnostic coding.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
