Manifest Destiny is the belief that America was willed to occupy from the Atlantic coast to the Pacific coast, so the answer is A.
(C) For the longest time Europeans and other outsiders could not travel into central Africa due to the various disease they were not immune or accustomed to, as it meant almost certain death for anyone not native to the area.
Answer:
giving the "most power" to the national government, letting the president direct the executive branch, and having a "firm system of checks and balances"?