Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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38 ATP is produced during cellular respiration
Cross over? i have no idea lol
Since fish feeds primarily on large amphipod,
therefore what we expect to remain to evolve on ponds containing fish would be
smaller amphipod or crustacean. Then correct answer to this question would be:
<span>“Ponds with fish should have smaller amphipods.”</span>
Answer:
This means that the two separate rocks were once part of one piece of rock. These layers got separated most probably by continental drift as a result of tectonic plate movements. An example of such a fossil is the Mesosaurus, a freshwater crocodile-like reptile, that is found in Southern Africa and Eastern South America continents- that means they were once one land mass.
The environment in these two separate layers would most likely be different. As the layers drift apart from each other , they drift across latitudes that are determinants of climate in a region. Therefore, even the organisms in these two rock layers will evolve differently (even though they will share a common ancestor) in adaptation to respective environments – this is called allopatric speciation.
