Question

A patient was diagnosed with a deficiency of the lysosomal enzyme alpha-galactosidase. The name of the deficient enzyme suggest that it hydrolyzes a glycosidic bond, which best describes the bond that can’t be broken ?
A. multiple hydrogen bonds between two sugar molecules

B. BetweentheanomericcarbonofasugarandanOH(orN)of another molecule

C. Betweentwoanomericcarbonsinpolysaccharides

D. Internal bond formation between the anomeric carbon of a monosaccharide and
its own fifth carbon hydroxyl group.

E. Between the carbon containing the aldol or keto group and the α-carbon of the
sugar.

Answer 1

The best describes the bond that can’t be broken is B. Between the anomeric carbon of a sugar and an OH (or N) of another molecule

• Glycosidic bonds are a class of covalent bonds that joins a carbohydrate molecule to another group.

• A polysaccharide (where poly means 'many') is a long chain of monosaccharides linked by glycosidic bonds.

• Glycosidic bonds are formed between the hemiacetal group of a saccharide and the hydroxyl group (OH) of another compound  (e.g., alcohol).

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