Some of the social and cultural factors that led to the compromises in the drafting and ratification of the Constitution were over representation in congress, the powers of the president, how to elect the president, slave trade, and a bill of rights.
The answer is In 1791, the U.S. Congress passed the first internal revenue law, which placed a tax on distilled spirits and led to a 1794 armed rebellion by Pennsylvania farmers that became known as the "Whiskey Rebellion